Pharmaceutica Analytica Acta

Abstrait

Ancient Sources of Therapeutics

Shah Murad, Manal Raouf Mahar, Jamila Shah Murad, Seema Saif, Abdul Ghaffar Mastoi, Altaf Hussain and M Ishaq Mastoi

CHD tends to develop when cholesterol builds up on the artery walls, creating plaques. These plaques cause the arteries to narrow, reducing blood flow to the heart. Coronary Artery Disease is caused by plaque buildup in the walls of the arteries that supply blood to the heart (called coronary arteries) and other parts of the body. Plaque is made up of deposits of cholesterol and other substances in the artery. Plaque buildup causes the inside of the arteries to narrow over time, which could partially or totally block the blood flow. Coronary artery disease (CAD), when get worst, it is known as coronary artery syndrome (CAS). We compared Rosuvastatin 10 mg with Indian dates (Jujubes) as hypolipidemic agents. Their baseline parameters like LDL-cholesterol, HDL-cholesterol, systolic/diastolic blood pressure was determined in the hospital laboratory. It was observed that Rosuvastatin significantly decreased systolic/diastolic blood pressure, LDL-cholesterol, and increased HDL-cholesterol in 27 hyperlipidemic/hypertensive patients. Indian dates used in 30 hyperlipidemic patients significantly decreased systolic blood pressure, and LDL-cholesterol, but insignificant changes were seen in diastolic blood pressure, and HDL-cholesterol. We concluded from the research work that Rosuvastatin is potent hypolipidemic and hypotensive medicine as compared to indian dates.