Indexé dans
- Ouvrir la porte J
- Genamics JournalSeek
- CiteFactor
- Cosmos SI
- Scimago
- Répertoire des périodiques d'Ulrich
- Bibliothèque des revues électroniques
- RechercheRef
- Université Hamdard
- EBSCO AZ
- Répertoire d'indexation des résumés pour les revues
- OCLC - WorldCat
- Invocation de Proquête
- érudit
- ROUTE
- Bibliothèque virtuelle de biologie (vifabio)
- Publions
- Fondation genevoise pour la formation et la recherche médicales
- Google Scholar
Liens utiles
Partager cette page
Dépliant de journal
Revues en libre accès
- Agriculture et aquaculture
- Alimentation et nutrition
- Biochimie
- Bioinformatique et biologie des systèmes
- Business & Management
- Chimie
- Génétique et biologie moléculaire
- Immunologie & Microbiologie
- Ingénierie
- La science des matériaux
- Neurosciences & Psychologie
- Science générale
- Sciences cliniques
- Sciences environnementales
- Sciences médicales
- Sciences pharmaceutiques
- Sciences vétérinaires
- Soins infirmiers et soins de santé
Abstrait
Anti-oxidative and hepatoprotective effect of beta-carotene on acetaminophen-induced liver damage in rats
AO Morakinyo, BO Iranloye, OT Oyelowo, J Nnaji
The role of oxidative stress on the hepatic damage caused by acetaminophen (APAP) and the possible protective effects of beta-carotene supplement against this damage were investigated. The rats were randomly divided into four groups: control, APAP, beta-carotene, and APAP1beta-carotene. The control group received distilled water while APAP (750 mg/kg body weight), beta-carotene (10 mg/kg/day body weight) (BC) were administered to the other groups accordingly. The serum glutamate oxalate transaminase (SGOT), serum glutamic pyruvate transaminase (SGPT) as well as serum alkaline phosphatase (SAP) levels of APAP group were significantly increased when compared with the control (p , 0.01). This was ameliorated by the administration of beta-carotene. The SOD, GSH, and CAT levels of the APAP groups which were significantly decreased (p , 0.001) when compared with the control. There was a boost in the antioxidant level after the application of BC. The reverse was the case in the malondialdehyde (MDA) activity. The study showed that BC will ameliorate the damaging effect of APAP on liver tissues.