Diabetes Case Reports

Abstrait

Development of novel technology for continuous glucose monitoring

You-Ling Ding

A Diabetes mellitus (DM) is a group of metabolic disorders characterized by high glucose levels and poor glucose control over a prolonged period of time. Acute complications include diabetic ketoacidosis (DKA), hyperosmolar hyperglycemic state (HHS), and hypoglycemia which can lead to seizure or even death. Chronic complications include retinopathy, nephropathy, cardiovascular disease, cerebrovascular disease, and neuropathy. Strict glycemic control, medication, insulin injections, diet, and exercise can delay or prevent these complications.  
Crucial to diabetes management is patient monitoring of glucose levels several times per day, either using selfmonitoring blood glucose meters (SMBG) or continuous glucose monitors (CGMs). SMBGs measure blood glucose levels in capillary blood collected from the finger. The pain and inconvenience of this method leads many patients to test less frequently than their physicians suggest. CGMs provide interstitial glucose readings every few minutes using a sensor implanted under the skin.  
A novel CGM device was developed to continuously monitor glucose and ketone levels to rapidly detect the onset of acute complications. Research on a novel multi-biomarker continuous glucose monitoring (CGM) device is being conducted by the device inventor, Seknova Biotechnology. The multi-biomarker CGM device continuously monitors glucose and ketones levels in diabetic patients to rapidly detect the development of acute complications. Current testing on diet-induced diabetic mice shows high accuracy in glucose monitoring across glycemic ranges 
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