Biology and Medicine

Abstrait

Effect of sodium selenite on cisplatin-induced testicular lesions in adult male rats

Dilek Burukoglu Donmez and Seren Bozdoğan

Cisplatin is a well-known chemotherapeutic substance commonly used in the treatment of cancer. Several reports have been published on its antineoplastic activity and toxicity, but no details are available on its harmful effects on the organs of the genital system such as the testes. Another interesting element, selenium and its derivatives, including sodium selenite, are thought to form the active center of glutathione peroxidase, which has antioxidant properties involved in the antioxidant balance of cells and lipid peroxidation. This study aimed to explore the effects of selenium against the damage caused to rat testes by cisplatin treatment. Twenty-eight Sprague-Dawley rats were randomly assigned to different standard and treatment groups. All animals in the different experimental groups were kept under standard controlled conditions. The results clearly demonstrated that cisplatin treatment decreased the testicular weight as well as the body weight of rats. In addition, it damaged the seminiferous tubules and testicular cells of animals in the treatment groups and stopped the process of spermatogenesis. Selenium treatment reduced the damage caused by cisplatin treatment. The results of the present study were confirmed by detailed histopathological examinations