Indexé dans
- Ouvrir la porte J
- Genamics JournalSeek
- Clés académiques
- JournalTOCs
- Infrastructure nationale des connaissances en Chine (CNKI)
- Répertoire des périodiques d'Ulrich
- RechercheRef
- Université Hamdard
- EBSCO AZ
- Répertoire d'indexation des résumés pour les revues
- OCLC - WorldCat
- Publions
- Fondation genevoise pour la formation et la recherche médicales
- Pub européen
- Google Scholar
Liens utiles
Partager cette page
Dépliant de journal
Revues en libre accès
- Agriculture et aquaculture
- Alimentation et nutrition
- Biochimie
- Bioinformatique et biologie des systèmes
- Business & Management
- Chimie
- Génétique et biologie moléculaire
- Immunologie & Microbiologie
- Ingénierie
- La science des matériaux
- Neurosciences & Psychologie
- Science générale
- Sciences cliniques
- Sciences environnementales
- Sciences médicales
- Sciences pharmaceutiques
- Sciences vétérinaires
- Soins infirmiers et soins de santé
Abstrait
Embryonic Stem Cells: A Perfect Tool for Studying Mammalian Transcriptional Enhancers
Sridhar Rao
Transcriptional enhancers are DNA elements capable of regulating gene expression in-cis over great distances. With the recent availability of genomic approaches to define epigenetic marks and RNA levels, these previously difficult to study elements are now being extensively examined for their critical role in lineage-specific transcriptional regulation. This review sets out to highlight the use of embryonic stem cells (ESCs) in the study of enhancers, emphasizing that ESC have become an ideal model system for questions regarding mammalian transcriptional regulation. This review highlights the epigenetic “signature” of enhancers, their mechanism of action, and the role of non-coding RNAs (ncRNAs) on enhancer function. We briefly review insulators, a sub-type of enhancers, and a novel model system for studying enhancer function in vivo. We conclude with some ongoing questions within the field.