Md. Reyad-ul-Ferdous, Tamara Towshin Alam, Md. Atiqul Islam, Md. Zahirul Islam Khan, Fariha Tasnim, Md Eshak Khan, Md Sharif Ullah and Tazmel Haque
In the present study, Parmentiera cereifera fruit extract was subjected to comparative evaluation of cardioprotective and cytotoxic activities on brine shrimp (Artemia salina) in comparison with standard streptokinase (SK) and vincristine sulfate (VS). Crude methanolic extract (ME), hexane soluble fraction (HXSF), carbon tetrachloride soluble fraction (CTCSF), water soluble fraction (AQSF) and chloroform soluble fraction (CSF) of P. cereifera fruits were subjected to these studies. In the thrombolytic study, crude methanolic extract (ME) and hexane soluble fraction (HXSF) showed mild to moderate thrombolytic activity (2.5-21.50%) in human blood sample in comparison with standard streptokinase (SK) 66.77%. The fruit extracts were found to be (1.78 to 79.90) significantly cytotoxic to A. salina with LC50 values ranging from 6.07 to 7.83 µg/mL compared to the standard vincristine sulfate (VS, LC50 value 0.45 µg/mL).