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Abstrait
HIV infection-induced immunosuppression
Mohamed G Elfaki
Immunosuppression due to HIV infection results from several factors including defective innate signaling pathways, increased viral replication and viral load, progressive loss of peripheral CD4+ T cells, and decreased mucosal T cells that collectively lead to progressive immune deficiency and development of AIDS. T cells derived from HIV patients were anergic and failed to mount a robust adaptive immune response. The host, on the other hand, becomes vulnerable to opportunistic infections such as tuberculosis and AIDS-related cancers such as Kaposi's sarcoma, non-Hodgkin's lymphoma, and cervical cancer with a remarkable level of immunosuppression. Elucidation of the various mechanisms involved in these immunological disturbances is necessary to understand HIV pathogenesis for effective immunotherapy.