Indexé dans
- Ouvrir la porte J
- Genamics JournalSeek
- Clés académiques
- JournalTOCs
- RechercheBible
- Bibliothèque des revues électroniques
- RechercheRef
- Université Hamdard
- EBSCO AZ
- OCLC - WorldCat
- Invocation de Proquête
- Catalogue en ligne SWB
- Bibliothèque virtuelle de biologie (vifabio)
- Publions
- MIAR
- Pub européen
- Google Scholar
Liens utiles
Partager cette page
Dépliant de journal
Revues en libre accès
- Agriculture et aquaculture
- Alimentation et nutrition
- Biochimie
- Bioinformatique et biologie des systèmes
- Business & Management
- Chimie
- Génétique et biologie moléculaire
- Immunologie & Microbiologie
- Ingénierie
- La science des matériaux
- Neurosciences & Psychologie
- Science générale
- Sciences cliniques
- Sciences environnementales
- Sciences médicales
- Sciences pharmaceutiques
- Sciences vétérinaires
- Soins infirmiers et soins de santé
Abstrait
Pharmacogenomics of Cytochrome P450 Dependent Metabolism of Endogenous Compounds: Implications for Behavior, Psychopathology and Treatment
Anna Persson and Magnus Ingelman-Sundberg
Mood and anxiety disorders are a major burden to the society today but still the pathophysiology behind these disorders is largely unknown and the pharmacotherapy available today is far from sufficient, with relatively low remission rates. Recent results regarding the action of CYP2C19 and CYP2D6 in the CNS suggest associations between suicidality, anxiety and other stress-related disorders and such CYP enzyme polymorphisms. Knowledge about the CNS specific action of these enzymes might in the future provide an increased understanding of the pathogenesis and pathophysiology of these disorders. Here we present an update of the research carried out in human and animal models with focus on the roles of CYP2C19 and CYP2D6 for brain development and function mediated by the metabolism of endogenous compounds.