Advances in Pharmacoepidemiology and Drug Safety

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Possible Relationship between Zonulin, Metformin and Insulin Resistance in Polycystic Ovarian Women

Manal Abdulmunem Ibrahim

Zonulin protein is important to increase gut permeability, and its level is correlated with insulin resistance in polycystic ovarian women. Also, estrogen level is correlated with serum zonulin. Metformin, an insulin sensitizing drug can decrease serum zonulin in those patients. It is important to do new researches to know the mechanism of hormonal, and metformin effects on zonulin.