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Abstrait
Predicting the Possible Mechanism of Aphrodisiac Action of Pheonix Dactylifera L
Ben Enoluomen Ehigiator, Agnes Eno Cobhams, Elias Adikwu, Inemesit Okon Ben
Background: There are several methods and remedies available for managing sexual dysfunction, a major issue man, among such is the use of aphrodisiacs. There is still the search for aphrodisiac agents, especially those from natural or plant-based sources and Pheonix dactylifera (P. dactylifera) has a potential aphrodisiac effect. This study was designed to investigate the possible mechanism of its aphrodisiac action using the molecular docking technique, which was to dock compounds unto target proteins that contribute to the management of erectile dysfunction. The key targets used for this study are; phosphodiesterase-5 (PDE-5, arginase II, aromatase, angiotensin-converting enzyme ACE, and alpha-1 adrenoceptors).
Methods:About 49 compounds were obtained from Pubchem library, by virtual screening of articles related to P. dactylifera, ligand library generated and docked against various targets of interest, concerning the penile erection and erectile dysfunction.
Results:Rutin, pelargonin, procyanidins, quercetin, and procyanidins showed good docking scores on some of the targets considered for the study.
Conclusion: Rutin, pelargonin, procyandins may be potential drugs for ED