Pharmacologie cardiovasculaire : libre accès

Abstrait

Role of 99mTc- SPECT-CT Myocardial Perfusion (MPI) Is Sensitive and Accurate in the Management of Coronary Artery Disease

Karan Peepre

Myocardial Perfusion Imaging in Nuclear cardiology is a head-way specialty that is convenient from technological and Radiopharmaceutical point of view. It is found that there has been an increase in the accuracy & sensitivity of myocardial perfusion imaging (MPI) with gated single photon emission computed tomography (SPECT) using 99mTc- sestamibi for assessing the diagnosis and prognosis of coronary artery disease. Furthermore, SPECT/CT with ECG gating allows the simultaneous assessment of both myocardial perfusion imaging (MPI) and left ventricular function (LVF). With rising concern for early detection of CAD and its effective treatment, MPI is ideally placed to provide complete functional assessment for the patient, regardless of their treadmill capacity. On the basis of Myocardial Perfusion Studies of 166 patients in one year with moderate to severe coronary artery disease (CAD) performed at All India Institute of Medical Sciences Raipur India, using (99m)Tc-methoxy-isobutyl-isonitrile ((99m)Tc-MIBI). Out of which TMT stress positive findings are 45 and 48 patients were normal and in pharmacological stress 37 were positive and 13 were normal. Also there were only rest scans in which 15 were positive and 8 were normal. The aim of this study was to find the accuracy and sensitivity in the management of coronary artery disease (CAD). Acquisition parameters for stress and rest phases to achieve the highest sensitivity and accuracy rate for (99m)Tc-MIBI SPECT. Myocardial perfusion imaging (MPI) with SPECT was performed on the basis of one-day protocol with stress- and rest-phase images obtained at 45 to 60 minutes after injection of 8mCi & 22mCi (99m)Tc-MIBI respectively. According to the parameters of image acquisition at stress/rest phases, sensitivity and specificity of one-day protocols for MPI with (99m)Tc-MIBI is represented in following table respectively.