Journal des maladies tropicales et de la santé publique

Abstrait

Sickle Cell Disease Clinical Trials and Phenotypes

Chinedu A Ezekekwu, Taiwo R Kotila, Titilola S Akingbola, Guillaume Lettre, Victor R Gordeuk, Richard S Cooper, Michael R DeBaun, Baba Inusa, Bamidele O Tayo and on behalf of the Africa Sickle Cell Research Network (AfroSickleNet)

More recent evidence however suggests the likelihood of four independent mutations of the sickle cell gene in different populations; three of which occurred in Africa. The trans-Atlantic slave trade accounted for the gene movement from Africa to the Caribbean and United States of America and lately migration has resulted in the introduction of the gene to the United Kingdom and other parts of Europe. The incidence of SCD in England (1:200 births) is increasing and the high prevalence is due to the high percentage of births to mothers of West African origin.