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Abstrait
Synthesis of Biological Active Esters of the Isovaleric Acid by Isobutylene Hydroalkoxycarbonylation
Suerbaev KA, Zhaksylykova GZ, Appazov NO
Hydroalkoxycarbonylation of 2-methylpropene with carbon monoxide and alcohols under condition of homogeneous catalysis with transition metal complexes allows facile one-step synthesis of practically useful isovaleric acid esters. Many of them exhibit biological activity and are constituents of drugs (Validolum, Corvalolum, etc.) or valuable intermediate products in drug synthesis. Biological active isovaleric acid esters (1-menthylisovalerate, ethylisovalerate, cyclohexylisovalerate, benzylisovalerate, α-monoglyceryde of isovaleric acid) were prepared by isobutylene hydroalkoxycarbonylation. New efficient technologies for preparation of drugs (Validolum, Ethyl ester of α-bromisovaleric acid and Corvalolum) are based on the isovaleric acid esters were worked out.