Journal des troubles sanguins et de la transfusion

Abstrait

The Effect of Crystalloid vs. Crystalloid plus Colloid Infusion on the Coagulation System in Patients Undergoing Cancer Breast Surgery

Eman Nasreldin, Nagwa Gamal and Abeer M Darwish

Background: To explore whether administration of routinely used intravenous solutions differently affects the coagulation system in breast cancer patients undergoing surgery receiving crystalloid alone or plus colloid fluid regimen.

Patients and Methods: The study included 60 female cancer breast patients scheduled for surgery; patients were randomized to undergo acute normovolemic hemodilution with either crystalloid or crystalloid plus colloid. Six samples were collected from each patient at different period of the study.

Results: IV administration of crystalloid plus colloid as well as crystalloid fluid cause significant effect in coagulation factors variables which is more obvious in administration of both crystalloid and colloid fluid together; where most investigated coagulation variables were significantly increased or decreased. This recorded variation reverts to normal value after 24 hour of infusion samples

Conclusion: Generally the least effect was observed in the group receiving crystalloid; special consideration should be given to the use of colloid rather than crystalloid solutions for rapid fluid loading.