Indexé dans
  • Genamics JournalSeek
  • JournalTOCs
  • CiteFactor
  • Répertoire des périodiques d'Ulrich
  • RechercheRef
  • Université Hamdard
  • EBSCO AZ
  • Répertoire d'indexation des résumés pour les revues
  • OCLC - WorldCat
  • Publions
  • Fondation genevoise pour la formation et la recherche médicales
  • Pub européen
  • Google Scholar
Voir plus
Liens utiles
Partager cette page
Dépliant de journal
Flyer image
Revues en libre accès
Voir plus

Abstrait

The Impact of Strontium Ranelate on Implant Osseointegration of Osteoporosis in Vivo Experiment

Maiquan Wang,Qingqing Liu,Chao Yang,Yuanyuan Zhang*

Objective: To investigate the impact of strontium ranelate on implant osseointergration of osteoporotic rats in vivo experiment.

Method: Thirty-six female rats were randomly divided into three groups: ovariectomization group (A=12), strontium ranelate low-dose treatment group (B=12) and strontium ranelate high-dose treatment group (C=12). After the success of the osteoporosis model building, HA coated titanium implants were inserted into proximal metaphyses of tibiae, meanwhile, the rats of group B and C received oral medication of strontium ranelate (B: 450 mg/kg.d C: 900 mg/kg.d), 12 weeks after surgery, animals were killed and decalcified sections were prepared and examined histologically and histomorphometrically, as well as micro-CT examination.

Results: 12 weeks after implantation surgery, bone mineral density (BMD), implant bone contact rate (IBCR) and new bone volume (NBV) in group B and C were significantly higher compared with group A (p<0.01).

Conclusion: Strontium ranelate may resist the negative influence of osteoporosis and promote osseointergration of implant.

Avertissement: Ce résumé a été traduit à l'aide d'outils d'intelligence artificielle et n'a pas encore été examiné ni vérifié