Journal de médecine vasculaire et de chirurgie

Abstrait

The Platelet-Lymphocyte Ratio Predict the Risk of Amputation in Critical Limb Ischemia

Murat Songur C, Erdal Simsek, Omer Faruk Cicek, Kemal Kavasoglu, Sameh Alagha, Mehmet Karahan, Tugba Avcı and Irfan Tasoglu

Background: The aim of this study was to PLR (paltelet-lymphcyte ratio) might represent significant prognostic indices in patients with CLI (critical limb ischemia) and might provide superior prognostic information.

Materials and methods: One hundred and fourty one patients presented with CLI to our hospital between February 2007 and June 2012 who could not have radiological or surgical revascularization and had medical treatment are included in our study (n:133). Primary end point was determined as amputation (limb survival) and all-cause death and separate analyses were performed.

Results: Out of the 133 patients in the study. There were a total of 28 (26.9%) deaths and 46 (34%) amputation over a mean follow-up of 46 months. The amputations were above ankle in 24 (77%), below ankle in 7 (23%). All patients were grouped in two, those undergone amputation and those without amputation. Diabetes mellitus, hemoglobin and platelet levels, mean PLR, PLR ≥ 160 were strong univariable predictor of amputation.

Conclusion: Significant prognostic information can be obtained from routine blood results in patients with CLI. Stratification of CLI patients according to admission PLR should be considered in the limb survival analyses of future adjuvant and neoadjuvant trials to validate these findings.