Biochimie & Biochimie Analytique

Abstrait

Biophysical and Biochemical Transmutation of Mitochondrial Function in Cancer Genesis

Ponizovskiy MR

Interactions between nuclear processes and mitochondrial processes determine stabile basophilic chemical potential in cytoplasm, i.e. stability cellular Internal Energy and Internal Medium. Interactions between all cells of an organism occur due to remote reactions across distance as the results of cellular capacitors operations via production of resonance waves. Interactions between cellular capacitors of cells maintain common stability of Internal Energy and Internal Medium both in cells and in an organism. Considering mechanism maintenance stability cytoplasm of cell there were explained differences between mechanisms occurring in mitochondria of normal cellular cycle and in mitochondria of oncologic cellular cycle which displays mitochondrial mechanism of oncogenesis. The role mitochondrial DNA and production complex ROS/H2O2/free radicals in mitochondrial function of both normal cellular cycle and oncologic cellular cycle were explained from the point of view of the offered concepts. The outcomes of some investigations of development processes in cancer cells’ mitochondria were critical reviewed from the point of view of offered concepts, and results some experiments were explained eliminating doubts which were expressed by the authors of these experiments. Also there was presented benefits of mitochondrial targeting via the new possibility of cancer disease treatment.