Biochimie & Biochimie Analytique

Abstrait

MicroRNAs are Emerging as Most Potential Molecular Biomarkers

Sanjay Yadav, Abhishek Jauhari, Nishant Singh, Tanisha Singh, Ankur Kumar Srivastav, Parul Singh, AB Pant and Devendra Parmar

Broadly biomarker word is defined as quantifiable indicator of disease conditions or physiological changes of living organisms. Biomarker field is very old, only few specific biochemical and molecular biomarkers are identified. Discovery of novel and specific biomarkers is still facing several challenges . Based on the methods of quantification, biomarkers can be classified in three types 1) Imaging biomarkers (like X-ray, ultra sound, CT scan, PET, MRI), 2) Biochemical biomarkers (transaminases, bilirubin, alkaline phosphatase, serum creatinine) and 3) Molecular biomarkers. Molecular biomarkers are defined as markers which are measured based on genomic and proteomic approaches. Molecular biomarkers are most recent development in biomarker field, which is still in early developmental stage and needs tremendous amount of research to identify the specific biomarkers which can help in detection of disease before onset of physio; pathological changes or symptoms.