Indexé dans
- Ouvrir la porte J
- Genamics JournalSeek
- RechercheBible
- RechercheRef
- Répertoire d'indexation des revues de recherche (DRJI)
- Université Hamdard
- EBSCO AZ
- OCLC - WorldCat
- érudit
- Publions
- MIAR
- Pub européen
- Google Scholar
Liens utiles
Partager cette page
Dépliant de journal
Revues en libre accès
- Agriculture et aquaculture
- Alimentation et nutrition
- Biochimie
- Bioinformatique et biologie des systèmes
- Business & Management
- Chimie
- Génétique et biologie moléculaire
- Immunologie & Microbiologie
- Ingénierie
- La science des matériaux
- Neurosciences & Psychologie
- Science générale
- Sciences cliniques
- Sciences environnementales
- Sciences médicales
- Sciences pharmaceutiques
- Sciences vétérinaires
- Soins infirmiers et soins de santé
Abstrait
Synthesis and SAR Studies of Potent Antioxidant and Anti-Inflammatory Activities of Imidazole Derived Schiff Base Analogues
Shantharam CS, Swaroopa M, Darshini N, Mallesha N and Rakesh KP
A novel sequence of imidazole derived Schiff base analogues 4-23 were synthesized and characterized by spectroscopic and analytical techniques. The in vitro antioxidant activities of these compounds were evaluated by using DPPH, ABTS and DMPD assay. The results exposed that the IC50 of compounds 9, 10, 11, 15, 16, 22 and 23 were lower than that of standards in all the three tested antioxidant assays indicating good activities of these compounds. In vitro anti-inflammatory activities of the synthesized compounds were tested and the outcomes of results were confirmed that the compounds 5, 6, 7, 8, 12, 13, 14 and 21 exhibited excellent anti-inflammatory activity. Preliminary structure-activity relationship revealed that the compounds 9, 10, 11, 15, 16, 22 and 23 with electron donating moiety (OH, OCH3) were found to be excellent antioxidants and compounds 5, 6, 7, 8, 12, 13, 14 and 21 with electron withdrawing moiety (Cl, F, NO2 and Br) were found to be excellent anti-inflammatory agents.